Neurobiologia da resiliência: em busca de lesão por um futuro consciente
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Este estudo traz a luz os marcadores biológicos relevantes para a resiliência, através de uma revisão sistematizada da literatura, e à semelhança do estudo das lesões cerebrais, que para tentar compreender as funções dessas estruturas lesionadas, observam-se quais as funções que deveriam e não estão activas, fomos estudar as patologias em que as funções mais expressivas de resiliência – sociais, de adaptabilidade e flexibilidade – estão comprometidas. Caso da Perturbação Pós-Stress Traumático, pela sua natureza evidente de gestão do stress/trauma, bem como da Perturbação Anti-Social da Personalidade e Autismo, por serem patologias indicadas pela literatura – pese embora ainda muito da sua etiologia por esclarecer – resultantes de condicionalismos não somente ambientais – ou seja, com potencialidade para agravar a situação patológica ou beneficiar das condições ambientais, e por isso não necessariamente irreversíveis na sua amplitude – mas também resultantes de condicionalismos congénitos e observáveis desde os primeiros ciclos de vida, contrariamente às Perturbações Psicóticas, de Humor, ou outra do domínio da Ansiedade, as quais podem surgir ao longo dos vários ciclos da vida, ou terem outras funções comprometidas que não aquelas cujos critérios de diagnóstico dominante corresponda às funções que pretendemos observar. Assim, concluímos que os marcadores mais relevantes são: oxitocina e vasopressina, cortisol, dehidroepiandrosterona, glicose, catecolaminas e serotonina.
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Referências
Aiello, T.P. & Whitaker-Azmitia, P.M. (2011). Sexual differentiation and the neuroendocrine hypothesis of autism. Anat Rec (Hoboken) 294(10):1663-70.
Bales, K.L. & Perkeybile, A.M. (2012). Developmental experiences and the oxytocin receptor system. Horm Behav. 61(3):313-9.
Barraza, J.A., Grewal, N.S., Ropacki, S., Perez, P., Gonzalez, A. & Zak, P.J. (2013). Effects of a 10-Day Oxytocin Trial in Older Adults on Health and Well-Being. Exp Clin Psychopharmacol.
Bauer, M.E., Wiek, A., Lopes, R.P., Teixeira, A.L & Grassi-Oliveira, R. (2010). Interplay between neuroimmunoendocrine systems during post-traumatic stress disorder: a minireview. Neuroimmunomodulation. 17:92-5.
Bowirrat, A., Chen, T.J., Blum, K., Madigan, M., Bailey, J.A., Chuan Chen, A.L., Downs, B.W., Braverman, E.R., Radi, S., Waite, R.L., Kerner, M., Giordano, J., Morse, S., Oscar-Berman, M. & Gold, M. (2010). Neuro-psychopharmacogenetics and Neurological Antecedents of Posttraumatic Stress Disorder: Unlocking the Mysteries of Resilience and Vulnerability. Curr Neuropharmacol 8(4):335-58.
Brang, D. & Ramachandran, V.S. (2010). Olfactory bulb dysgenesis, mirror neuron system dysfunction, and autonomic dysregulation as the neural basis for autism. Med Hypotheses 74(5):919-21.
Campbell, D.B., Datta, D., Jones, S.T., Batey, Lee E., Sutcliffe, J.S., Hammock, E.A. & Levitt, P. (2011). Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder. J Neurodev Disord. 3(2):101-12.
Deeley, Q., Daly, E., Surguladze, S., Tunstall, N., Mezey, G., Beer, D.,… Murphy, D.G.(2006). Facial emotion processing in criminal psychopathy. Preliminary functional magnetic resonance imaging study. The British Journal of Psychiatry, 189, 533-539.
Diamantopoulou, S., Verhulst, F.C. & Van Der Ende, J. (2009). Testing Developmental Pathways to Antisocial Personality Problems. Journal of Abnormal Psychology, 118.
Feldman, R. (2012). Oxytocin and social affiliation in humans. Horm Behav. 61(3):380-91.
Fontaine, G., Yang, C., Dodge, K., Pettit, G. & Bates, J. (2009). Development of Response Evaluation and Decision (RED) and Antisocial Behavior in Childhood and Adolescence. Developmental Psychology, 45, 447-459.
Fox, A. R., Kvaran, T. H. & Fontaine, R. G. (2011). Psychopathy and Culpability: How responsible is the psychopath for criminal wrongdoing?. http://works.bepress.com/ reid_fontaine/28.
Gallardo-Pujol, D., Forero, C.G., Maydeu-Olivares & A., Andrés-Pueyo, A. (2009) The development of antisocial behavior: psychobiological and environmental factors and gene-environment interactions. Rev Neurol, 48, 191-8
Ghafoori, B., Hierholzer, R., Howsepian, B. & Boardman, A. (2008) The role of adult attachment, parental bonding, and spiritual love in the adjustment to military trauma. Journal of Trauma and Dissociation 9(1):85-106.
Glass, J. S. & Newman, P. J. (2009). Emotion Processing in the Criminal Psychopath: The Role of Attention in Emotion-Facilitated Memory. Journal of Abnormal Psychology, 118, 229-234.
Gurrieri, F. & Neri, G. (2009). Defective oxytocin function: a clue to understanding the cause of autism?. BMC Medicine 7:63.
Hadjikhani, N. (2010). Serotonin, pregnancy and increased autism prevalence: is there a link?. Medical Hypotheses 74(5):880-3.
Hansen, A., Johnsen, B., Thornton, D., Waage, L. & Thayer, J. (2007). Facets of Psychopathy, Heart Rate Variability and Cognitive Function. Journal of Personality Disorders, 21, 568-582.
Hansen, A., Johnsen, B., Hart, S., Waage, L. & Thayer, J. (2008). Brief Communication: Psychopathy and Recognition of Facial Expressions of Emotion. Journal of Personality Disorders, 22, 639-645.
Hawes, D.J., Brennan, J. & Dadds, M.R. (2009). Cortisol, callous-unemotional traits, and pathways to antisocial behaviour. Current Opinion in Psychiatry, 22, 357-62.
Hinterhuber, H. (2008). Psychiatry and the assessment of human destructiveness: on the question of drawing the line between the “normal” concept of evil and psychiatric illness. Neuropsychiatrie, 22, 198-213.
Hoff, H., Beneventi, H., Galta, K. & Wik, G.(2009). Evidence of Deviant Emotional Processing in Psychopathy: A fMRI Case Study. International Journal of Neuroscience, 119, 857-878.
Karreman, A. & Vingerhoets, J. J. M. (2012). Attachment and well-being: the mediatingrole of emotionregulation and resilience. Pers. Individ. Dif. 53:821–826.
Kumari, V., Das, M., Taylor, P.J., Barkataki, I., Andrew, C., Sumich, A., ... Ffytche, Dh. (2009). Neural and behavioural responses to threat in men with a history of serious violence and schizophrenia or antisocial personality disorder. Schizophrenic Research, 110, 47-58.
Lobbestael, J., Arntz A., Cima M. & Chakhssi, F. (2009). Effects of induced anger in patients with antisocial personality disorder. Psychological Medicine, 39, 557-568.
Lopez, A. (2011). Posttraumatic stress disorder and occupational performance: building resilience and fostering occupational adaptation. Work.38 (1):33-8.
Iversen, A.C., Fear, N.T., Ehlers, A., Hacker Hughes, J., Hull, L., Earnshaw, M., … Hotopf, M.(2008). Risk factors for post-traumatic stress disorder among UK Armed Forces personnel. Psychological Medicine. 38(4):511-22.
Jovanovic, T., Norrholm, S.D., Blanding, N.Q., Phifer, J.E., Weiss, T., Davis, M., … Ressler, K. (2010). Fear potentiation is associated with hypothalamic-pituitary-adrenal axis function in PTSD. Psychoneuroendocrinology 35(6):846-57.
Kortesluoma, S. & Karlsson, H. (2011). Oxytocin, a neuropeptide regulating affection and social behavior. Duodecim 127(9):911-8.
Lahey, B., Michalska, K. & Akitsuki, Y.(2008). Atypical Empathetic Responses in Adolescents with Aggressive Conduct Disorder: A functional MRI Investigation. Biological Psychology. Acedido em 20, Novembro, 2009, em http://news.uchicago.edu/images/pdf/081107 Decety_BiologicalPsi2008.pdf
Miller, M., Bales, K.L., Taylor, S.L., Yoon, J., Hostetler, C.M., Carter, C.S. &, Solomon, M. (2013). Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms. Autism Res. doi: 10.1002/aur.1270.
Miller, M.W., McKinney, A.E., Kanter, F.S., Korte, K.J. & Lovallo, W.R. (2011). Hydrocortisone suppression of the fear-potentiated startle response and posttraumatic stress disorder. Psychoneuroendocrinology 36(7):970-80.
Nowotny, B., Cavka, M., Herder, C., Löffler, H., Poschen, U., Joksimovic, L., … Kruse, J. (2010). Effects of acute psychological stress on glucose metabolism and subclinical inflammation in patients with post-traumatic stress disorder. Hormone and Metabolic Research 42(10): 746-53.
Pervanidou, P. & Chrousos, G.P. (2010). Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome. Progress in Brain Research. 182:149-60.
Pridmore, S., Chambers, A. & McArthur, M. (2005). Neuroimaging in psychopathy. Aust N Z J Psychiatry, 39, 856-65.
Radant, A.D., Dobie, D.J., Peskind, E.R., Murburg, M.M., Petrie, E.C., Kanter, E.D., … Wilkinson, C.W. (2009). Adrenocortical responsiveness to infusions of physiological doses of ACTH is not altered in posttraumatic stress disorder. Frontiers in Behavioral Neuroscience 3:40.
Schwerdtner, J., Sommer, M., Weber, T. & Müller, J. (2004). Functional neuroanatomy of emotions. Psychiatrische Praxis. 31 Suppl 1:S66-7.
Schwerdtner, J., Sommer, M., Weber, T. & Müller, J. (2006). The role of emotions in psychopathology. The British Journal of Psychiatry, 189, 533-539.
Shamay-Tsoory, S. G., Harari, H., Aharon-Peretz, J. & Levkovitz, Y. (2009). The role of the orbitofrontal cortex in affective theory of mind deficits in criminal offenders with psychopathic tendencies. Cortex. 46(5):668-77.
Shirtcliff, E., Vitacco, M., Graf, A., Gostisha, B. A., Jenna, L., Merz, B. A. & Zahn-Waxler, C. (2009). Neurobiology and Callousness: Implications for the Development of Antisocial Behavior. Behavioral Sciences and the Law, 27, 137-171.
Skelton, K., Ressler, K.J., Norrholm, S.D., Jovanovic, T. & Bradley-Davino, B. (2012) PTSD and gene variants: New pathways and new Thinking. Neuropharmacology. 62(2):628-37.
Weber, S., Habel, U., Amunts, K. & Schneider, F. (2008). Structural Brain Abnormalities in Psychopaths – A review. Behavioral Sciences and the Law 26: 7-28.
Weisman, O., Zagoory-Sharon, O. & Feldman, R. (2012). Oxytocin administration to parent enhances infant physiological and behavioral readiness for social engagement. Biol Psychiatry 72(12):982-9.
Wu, G., Feder, A., Cohen, H., Kim, J.J., Calderon, S, Charney, D.S. & Mathé, A.A. (2013). Understanding resilience. Frontiers Behavioral Neuroscience 7:10.
Yang, Y., Raine, A., Colletti, P., Toga, W.A. & Narr, K.L. (2009). Abnormal temporal and prefrontal cortical gray matter thinning in psychopaths. Molecular Psychiatry, 14, 555-562.
Yang, Y., Raine, A., Colletti, P., Toga, W. A. & Narr, K. L (2009). Localization of Deformations Within the Amygdala in Individuals With Psychopathy. Arch Gen Psychiatry, 66, 986-994.